Skin aging is a process due to two different and fundamental processes: intrinsic and extrinsic. Intrinsic aging is related to the inevitable aging process that all organs of our body are subjected to and it’s dictated by hormonal changes occurring as we age (1). This changes lead to dryness, loss of elasticity, due to the degradation of collagen and ultimately wrinkles form. The extrinsic aging, on which we have a much higher control, is related to external factors, mainly UV rays that are involved in causing loss of elasticity and plump look due to the lost capability of the skin to keep the moisture in. The key molecule that has incredible abilities to maintain a youthful and hydrated skin is Hyaluronic Acid.

Hyaluronic Acid is a molecule that exists in different forms and dimensions in order to accomplish its diverse functions in our body. 50% of the total amount of Hyaluronic Acid is found in the skin (2) and the remaining part of it is distributed among ligaments, tendons and main arteries, maintaining its ability of water retention in each tissue of our body.

Hyaluronic Acid is implied in tissue healing, lubrication and of course hydration. The hydration of the skin is crucially influenced by the Hyaluronic acid bound with water molecules in the epidermis (the most external layer of the skin) and dermis (middle layer of the skin), while the preservation of moisture is related to an even deeper level of the skin (subcutaneous tissue).

Hyaluronic Acid is the key component in the skin matrix structure that keeps it stretched and elastic providing physical support and substance, acting as a filler thanks to its ability to retain moisture. The skin matrix, made up mostly of collagen and elastin, is what would remain after removing all the cells of your skin. It is in consequence, responsible for the structure and stability of the skin tissue. The structure alone though wouldn’t be able to maintain a youthful skin appearance as the Hyaluronic Acid makes the matrix structured. Without it the structure would still remain but no packing substances that keep it firm and plump. That’s exactly what happens when we start losing moisture in our skin: we age, our skin hydration decreases and with it the overall skin elasticity. This causes dryness in the skin and little by little fine lines and wrinkles start to appear.

Benefits of Topical Hyaluronic acid in Kleem Organics Serum 

  • Prevents the formation and development of wrinkles
  • Increases and stimulates the overall skin hydration
  • Retains and holds the water molecules for a moisturized and smooth skin
  • Boosts the overall skin elasticity
  • Stimulates and promotes collagen synthesis
  • Nourishes healthy skin cell growth
  • Promotes firm skin tone


One problem that all skin care cosmetics, which contain Hyaluronic Acid is the ability of this molecule to penetrate into the skin, through the epidermis first and dermis afterwards, in order to rebuild and sustain the skin matrix structure.

Typically many skin care products contain bigger forms of Hyaluronic Acid which despite their undisputable effects, can only penetrate the superficial area of the epidermis. The Hyaluronic Acid medium-to-large size forms, typically with a molecular weight above 20,000Da, wouldn’t be able to penetrate deeply into the skin reaching the deepest layers of the dermis and beyond, having a durable and long-lasting impact on the skin matrix.

For this reason Kleem Organics decided to invest more in its serum, being completely aware of having created the highest quality product with not only the perfect ingredients that address the skin care concerns related to premature aging, but also the highest bio-available form of its ingredients. Kleem Organics uses also minute sizes of Hyaluronic Acid, with a molecular weight between 5,000 to 20,000 Da which penetrate the dermis in noteworthy amounts for best moisturizing and skin-plumping results.

In order to increase even more the effects of retaining the moisture in our skin due to this magical molecule, Kleem Organics uses in its serum formulation, particular ingredients that stimulate indirectly the natural synthesis of Hyaluronic Acid.

1. Makrantonaky E, adjaye J, Herwig R, Brink TC, Groth D, hultschig C, et al. Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell. 2006;5:331-44. Doi:10.1111/j.1474-9726.2006.00223.x. (PubMed)

2. Reed RK, Lilja K, Laurent TC. Hyaluronan in the rat with special reference to the skin. Acta Physiol Scand. 1988;134:405-11. doi:10.1111/j.1748-1716.1988.tb08508x.(PubMed)